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During the first 24 wk of treatment but subsequently reached the lower detection limit in the second 24 wk of treatment.

Patients present considerable management problems as there are few alternative anti-inflammatory treatments available.

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Interest because stress during pregnancy causes elevations in plasma cortisol, and has been associated with female skewing of the sex ratio at birth (Navara 2010), which may be exacerbated in the offspring of CBG-deficient women.

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